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1.
Dev Psychol ; 60(5): 978-989, 2024 May.
Article in English | MEDLINE | ID: mdl-38512190

ABSTRACT

While negative associations between behavioral inhibition/shyness and social competence are well established for children from Western cultures, the directions of these associations have been inconsistent for Chinese children, partly due to the ongoing social-cultural changes in China. Drawing from three samples of young Chinese children (born between 2009 and 2019), we aim at examining how inhibition/shyness predicts cooperative behaviors and prosocial behaviors throughout early childhood. In Study 1 (N = 700, children aged between 36 and 72 months), mother-reported inhibition/shyness was negatively associated with mother-reported cooperative and prosocial behaviors during the preschool years. In Study 2 (N = 251, at 6, 15, 25, and 37 months of children's ages), mother-reported inhibition/shyness in infancy was negatively associated with mother-reported cooperative behaviors but was not related to observed cooperative behaviors at the early preschool age. Infancy inhibition/shyness was negatively associated with mother-reported and observed prosocial behaviors. In Study 3 (N = 95, at 14, 25, 38, and 60 months of children's ages), the inhibition/shyness trait, assessed by both observation and maternal report, did not predict any indicators of cooperative behaviors. Early childhood inhibition/shyness, however, still predicted fewer observed and mother-reported prosocial behaviors. On balance, our research supports a negative association between early inhibition/shyness and later prosocial behaviors. The mixed findings concerning cooperative behaviors are interpreted in light of sociopolitical changes in China during the past two decades. (PsycInfo Database Record (c) 2024 APA, all rights reserved).


Subject(s)
Child Behavior , Inhibition, Psychological , Shyness , Social Skills , Humans , Child, Preschool , Female , Male , China , Child Behavior/physiology , Child , Cooperative Behavior , Child Development/physiology , Infant , Social Behavior , East Asian People
2.
Front Psychol ; 14: 1163009, 2023.
Article in English | MEDLINE | ID: mdl-37303899

ABSTRACT

Background: COVID-19-related lockdowns and preschool closures resulted in many young children spending all their time at home. Some parents had to manage child care while working from home, and increased demands may have led them to experience considerable stress. Evidence indicates that among parents with young children, those who had pre-existing mental and physical conditions adapted less well than other parents. We considered associations between parental well-being and the home learning environment for young children. Method: We leveraged data from the nationally representative China Family Panel Studies. We analyzed longitudinal data collected before (2018) and during (2020) the pandemic. Participants were parents of 1,155 preschoolers (aged 3-5 years in 2020). Moderated mediation models were conducted. Maternal and paternal psychological well-being, depression, physical health, and physical illness in 2018 and 2020 were predictors. The frequency of marital and intergenerational conflicts in 2020 were mediators. Primary caregiver-reported engagement in home learning activities and family educational expenditure and parent-reported time spent on child care in 2020 were outcome variables. The number of COVID-19 cases in each province 3 months before the 2020 assessment was the moderator. Child, parental, and household characteristics and urbanicity were covariates. Results: Controlling for covariates, improvements in parental psychological well-being predicted more home learning activities and increases in paternal depression predicted less time spent by fathers on child care. Negative changes in maternal physical health predicted less family educational expenditure and mothers spending more time on child care. Family conflicts mediated the association between maternal physical illness in 2018 and family educational expenditure. The number of COVID-19 cases in a province (i) was positively associated with mothers spending more time on child care, (ii) moderated the association of improvements in maternal physical health and mothers spending less time on child care, and (iii) moderated the association of family conflicts and more family educational expenditure. Conclusion: The findings indicate that decreased parental psychological and physical well-being foretells reductions in monetary and non-monetary investment in early learning and care at home. Regional pandemic risk undermines maternal investment in early learning and care, especially for those with pre-existing physical conditions.

3.
Article in English | MEDLINE | ID: mdl-36883961

ABSTRACT

Polymer gels can be effectively applied to plug fractured reservoirs and carbonate cave strata. Herein, polyvinyl alcohol (PVA), acrylamide, and 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) were used as raw materials to prepare interpenetrating three-dimensional network polymer gels using formation saltwater in the Tahe oilfield (Tarim Basin, NW China) as a solvent. The effect of AMPS concentration on the gelation properties of PVA in high-temperature formation saltwater was analyzed. Further, the effect of PVA concentration on the strength and viscoelastic properties of polymer gel was studied. The polymer gel could retain stable continuous entanglement at 130 °C and exhibited satisfactory thermal stability. Continuous step oscillation frequency tests showed that it exhibited an excellent self-healing performance. Scanning electron microscopy images of the simulated core by gel plugging showed that the polymer gel could firmly fill the porous media, indicating that the polymer gel exhibits excellent application prospects in oil and gas reservoirs under high-temperature and high-salinity conditions.

4.
Cerebrovasc Dis ; 52(4): 363-375, 2023.
Article in English | MEDLINE | ID: mdl-36423584

ABSTRACT

INTRODUCTION: This meta-analysis assessed the predictors of symptomatic intracranial hemorrhage (sICH) after endovascular thrombectomy (EVT) for patients with acute ischemic stroke. METHODS: PubMed, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science were searched for studies published from inception to February 16, 2021. We included studies that evaluated the predictors of sICH after EVT. The random-effect model or fixed-effect model was used to pool the estimates according to the heterogeneity. RESULTS: A total of 25 cohort studies, involving 15,324 patients, were included in this meta-analysis. The total incidence of sICH was 6.72 percent. Age (MD = 2.57, 95% CI: 1.53-3.61; p < 0.00001), higher initial NIHSS score (MD = 1.71, 95% CI: 1.35-2.08, p < 0.00001), higher initial systolic blood pressure (MD = 7.40, 95% CI: 5.11-9.69, p < 0.00001), diabetes mellitus (OR = 1.36, 95% CI: 1.10-1.69, p = 0.005), poor collaterals (OR = 3.26, 95% CI: 2.35-4.51; p < 0.0001), internal carotid artery occlusion (OR = 1.55, 95% CI: 1.26-1.90; p < 0.0001), longer procedure time (MD = 18.92, 95% CI: 11.49-26.35; p < 0.0001), and passes of retriever >3 (OR = 3.39, 95% CI: 2.45-4.71; p < 0.0001) were predictors of sICH, while modified thrombolysis in cerebral infarction score ≥2b (OR = 0.61, 95% CI: 0.46-0.79; p = 0.0002) was associated with a decreased risk of sICH. There were no significant differences in the female gender, initial serum glucose, initial ASPECT score, atrial fibrillation, oral anticoagulants, antiplatelet therapy, intravenous thrombolysis, general anesthesia, neutrophil-to-lymphocyte ratio, and emergent stenting. CONCLUSIONS: This study identified many predictors of sICH. Some of the results lack robust evidence given the limitations of the study. Therefore, larger cohort studies are needed to confirm these predictors.


Subject(s)
Ischemic Stroke , Stroke , Humans , Female , Stroke/diagnostic imaging , Stroke/therapy , Stroke/complications , Ischemic Stroke/diagnostic imaging , Ischemic Stroke/therapy , Ischemic Stroke/complications , Intracranial Hemorrhages/diagnostic imaging , Intracranial Hemorrhages/epidemiology , Thrombectomy/adverse effects , Thrombectomy/methods , Cohort Studies
5.
Child Abuse Negl ; 134: 105931, 2022 12.
Article in English | MEDLINE | ID: mdl-36302286

ABSTRACT

BACKGROUND: Maternal personal history of childhood abuse has been found to predict child social-emotional problems; however, little is known about the intergenerational associations between maternal childhood abuse and child cognitive outcomes. OBJECTIVE: This study aims at examining the intergenerational associations of maternal childhood emotional abuse and physical abuse with child executive functions among Chinese families with preschoolers, and exploring how these associations are mediated by maternal perspective-taking skills and mother-child conflict. METHODS: Participants were 309 preschoolers (152 boys) aged 2-6 years and their mothers. Mothers reported on their childhood abuse histories, perspective taking, and mother-child conflict at baseline (T1). Five months later (T2), child executive functions including working memory, inhibitory control, and cognitive flexibility were assessed using five computerized tasks. RESULTS: After controlling for child gender and age, associations with child executive functions were found for maternal childhood emotional abuse, but not physical abuse. Specifically, severer childhood emotional abuse directly predicted lower levels of child cognitive flexibility. Furthermore, chained mediation paths were found from maternal childhood emotional abuse to lower levels of child working memory and inhibitory control through worse maternal perspective taking skills and then more mother-child conflicts. CONCLUSIONS: Our findings provide evidence for less optimal executive functions among preschoolers with emotionally abused mothers. Developing strategies to resolve the long-lasting impacts of maternal childhood emotional abuse may be important for reducing the risks of being unable to fully achieve the cognitive potentials of the next generation.


Subject(s)
Child Abuse , Mother-Child Relations , Male , Female , Child, Preschool , Child , Humans , Mother-Child Relations/psychology , Executive Function , Mothers/psychology , Child Abuse/psychology , China/epidemiology
6.
Article in English | MEDLINE | ID: mdl-35942370

ABSTRACT

To determine the curative effect and prognosis of Solitaire FR stent thrombectomy integrated with the suction thrombus on the treatment of acute middle cerebral artery occlusion (AMCAO). Based on the treatment, patients suffering from AMCAO were separated into the Solitaire FR group (Solitaire FR stent + suction thrombus) and suction group (suction thrombus). Modified thrombolysis in cerebral infarction grading, National Institutes of Health Stroke Scale (NIHSS) score, modified Rankin Scale score, and safety performance were compared between the two groups. The operation time in the suction group was obviously shorter than the Solitaire FR group (P < 0.05). Significant differences were observed in the NIHSS scores 1 week and 4 weeks after the operation between the Solitaire FR group and the suction group (P < 0.05). The NIHSS scores 1 week and 4 weeks after operation were significantly lower than those before operation (P < 0.05). NIHSS scores 1 week after operation did not show obvious difference (P > 0.05). The Solitaire FR group showed obvious lower NIHSS scores than the suction group 4 weeks after surgery (P < 0.05). Statistically obvious difference in cerebral infarction grading of modified thrombolysis between the Solitaire FR group and the suction group were observed (P < 0.05). The recanalization rate of the Solitaire FR group was obviously higher than the suction group (P < 0.05). The difference in the monthly modified Rankin Scale score was obvious (P < 0.05). The good prognosis rate of the Solitaire FR group was obviously higher than the suction group (P < 0.05). No obvious differences in the incidence of internal bleeding, reocclusion, and 3-month postoperative mortality were observed (P > 0.05). These results showed that the treatment of the Solitaire FR stent + suction thrombus in AMCAO patients has a good thrombus recanalization rate and is helpful in improving the prognosis and safety performance.

7.
Dev Psychol ; 58(10): 1875-1886, 2022 Oct.
Article in English | MEDLINE | ID: mdl-35771498

ABSTRACT

Based on the goodness-of-fit theory, the current research examined how parental socialization expectations and socialization practices in infancy predicted child social adjustment in the preschool year dependent on child characteristics in toddlerhood with a longitudinal sample of Chinese families. Participants were 272 Chinese mother-child dyads. Maternal socialization goals of child autonomy and obedience were assessed when the child was 6 months old. Maternal respect for autonomy and negative control were observed in free-plays at 15 months. Mothers reported child compliance and inhibitory control at 25 months and rated child externalizing behaviors at 37 months. Results showed that for children with low levels of compliance or high levels of inhibitory control, obedience socialization goals predicted more externalizing behaviors, whereas for children with high levels of compliance or low levels of inhibitory control, obedience socialization goals predicted fewer externalizing behaviors. Moreover, for children with high levels of inhibitory control, higher levels of respect for autonomy or lower levels of negative control foretold fewer externalizing behaviors. Conversely, for children with low levels of inhibitory control, lower levels of respect for autonomy or higher levels of negative control forecasted fewer externalizing behaviors. Together, our findings demonstrate that socialization expectations, socialization practices, and child characteristics are jointly predictive of social adjustment across early childhood and all the significant interactions are characterized by the pattern of a contrastive effect, therefore congruently supporting the goodness-of-fit hypotheses. (PsycInfo Database Record (c) 2022 APA, all rights reserved).


Subject(s)
Child Behavior , Socialization , Child , Child, Preschool , China , Female , Humans , Infant , Mother-Child Relations , Mothers , Social Adjustment
8.
Neuropsychiatr Dis Treat ; 17: 3531-3537, 2021.
Article in English | MEDLINE | ID: mdl-34908835

ABSTRACT

OBJECTIVE: The proteoglycan versican (VCAN) plays an important role in extracellular matrix (ECM) assembly, and diminished maintenance of the ECM has been increasingly regarded as an important factor in the development of intracranial aneurysms (IAs). Previous studies have revealed that single-nucleotide polymorphisms (SNPs) of the VCAN gene are associated with susceptibility to IAs in European or Japanese populations. However, the association between IA susceptibility and VCAN SNPs in the Eastern Chinese population remains unclear. This study aimed to investigate the associations of the SNPs rs251124, rs2287926, and rs173686 with IA susceptibility in the Eastern Chinese population. METHODS: A total of 162 patients with IA and 182 controls were enrolled in this study. The study was conducted between January 2017 and December 2020. SNP genotyping for rs251124, rs2287926, and rs173686 was performed using Kompetitive Allele Specific PCR (KASP) after DNA extraction. The SNP data were analysed with CFX Manager Software version 3.1 (Bio-Rad). RESULTS: rs251124 and rs173686 were significantly associated with susceptibility to IA. The frequency of rs251124-TT in IA was higher than in controls (OR =1.26, 95% CI: 1.07-1.49; P<0.01), and its risk mainly came from the T allele. Furthermore, logistic regression analysis showed that the T/T genotype and T allele of rs251124 were independent risk factors for IA (OR=1.726, 95% CI: 1.136-2.263; P=0.011). Moreover, the G/G genotype and G allele of rs173686 were associated with increased IA susceptibility (OR=2.52, 95% CI: 1.261-5.037; P=0.009). CONCLUSION: The SNPs rs251124 and rs173686 were strongly associated with genetic susceptibility to IA in the Eastern Chinese population; however, no such association was found in the SNP rs2287926 of VCAN. Our findings suggest that the VCAN gene is an IA susceptible gene that should be further studied as a screening marker for IAs.

9.
Front Psychol ; 12: 662356, 2021.
Article in English | MEDLINE | ID: mdl-34267701

ABSTRACT

This study aimed at examining the differences between Chinese youths with hearing loss (HL) and with typical hearing (TH) in emotion understanding (EU), parental emotional expressivity, and the associations between EU and parental emotional expressivity. The participants were 282 youths with HL (14.58 ± 3.42 years old) and 350 youths with TH (11.69 ± 2.49 years old). EU was measured by four visual-mode tasks, of which two involve language comprehension while the others do not. Parents reported positive and negative emotional expressivity on the Self-Expressiveness in the Family Questionnaire. Covariates were controlled for including socioeconomic status, parent gender, youth gender, age, intelligence, and teacher-reported comprehension difficulties. Results showed that the four EU tasks were more challenging for the youths with HL than for the youths with TH. The interaction effect of the two groups × 4 tasks was not significant, suggesting that the differences between the two groups of youths in EU were generally similar across the four tasks. The parents of the youths with HL did not differ from the parents of the youths with TH in how often they displayed positive and negative emotional expressivity. Multigroup regression analyses revealed that negative emotional expressivity was negatively related to EU in the youths with HL but not in the youths with TH. However, these two regression coefficients were not significantly different. Positive emotional expressivity was not related to EU in either group. In conclusion, this study extends the knowledge about the EU of Chinese youths with HL and emotion-related socialization of the parents of these youths.

10.
J Exp Child Psychol ; 206: 105099, 2021 06.
Article in English | MEDLINE | ID: mdl-33631633

ABSTRACT

Internalization of external rules is a behavioral manifestation of moral development during childhood, and its development has come to be understood from the view of a complex parenting-by-temperament process. To examine this developmental process, the current research investigated how maternal parenting behaviors and child effortful control foretell internalization throughout early to middle childhood with two longitudinal samples of Chinese mother-child dyads. In Study 1 (N = 226), maternal respect for autonomy and negative control during free plays at 15 months of age were observed. At 25 months, child cool and hot effortful control were measured with a Stroop-like categorization task and an externally imposed delay task. At 37 months, observed internalization of maternal rules was assessed. Results showed that for toddlers with high levels of cool effortful control, maternal respect for autonomy positively predicted later internalization. In Study 2 (N = 88), maternal respect for autonomy and negative control during free plays at 38 months of age were coded. At 60 months, child cool and hot effortful control were measured with a Stroop-like inhibition task and a delay-of-gratification task. Observed internalization of maternal and experimenter rules and mother-reported internalization in everyday life were assessed at 60 and 84 months. Results showed that for children low on either cool or hot effortful control, maternal respect for autonomy negatively predicted later internalization during childhood. Together, the current findings support an age-relevant goodness-of-fit model for internalization development in Chinese children throughout the first 7 years of life.


Subject(s)
Parenting , Temperament , Child , China , Female , Humans , Infant, Newborn , Mothers , Parent-Child Relations
11.
Neurobiol Aging ; 96: 267-276, 2020 12.
Article in English | MEDLINE | ID: mdl-33130544

ABSTRACT

This study investigated the impact of white matter hyperintensities (WMHs) on the progression from mild parkinsonian signs (MPS) to parkinsonism and Parkinson's disease (PD). Participants with MPS completed 5 years of follow-up. WMHs were divided into periventricular WMHs and deep WMHs according to magnetic resonance imaging scans. The diagnosis of MPS, parkinsonism, and PD was based on the motor portion of the Unified Parkinson's Disease Rating Scale. Cox proportional hazard models were used to identify the association between WMHs and MPS progression. Of the 636 participants, 166 (26.1%) with MPS developed parkinsonism and PD after follow-up. After adjusting for potential factors, severe WMHs were associated with an increased risk of MPS progression, moderate and severe periventricular WMHs and severe deep WMHs were associated with the risk of MPS progression, and severe WMHs were associated with the progression of gait/balance impairment, bradykinesia, and rigidity. Additionally, participants treated for vascular risk factors such as hypertension, diabetes mellitus, and hypercholesterolemia had a lower risk of MPS progression.


Subject(s)
Magnetic Resonance Imaging , Parkinson Disease/diagnostic imaging , White Matter/diagnostic imaging , Aged , Disease Progression , Female , Follow-Up Studies , Gait , Humans , Hypokinesia , Male , Middle Aged , Muscle Rigidity , Parkinson Disease/pathology , Parkinson Disease/physiopathology , Postural Balance , Risk , Severity of Illness Index , Time Factors , White Matter/pathology
12.
Eur Neurol ; 82(4-6): 99-105, 2019.
Article in English | MEDLINE | ID: mdl-31865320

ABSTRACT

OBJECTIVE: To explore the relationship between metabolic syndrome (MetS) and cognitive impairment in elderly patients with white matter lesions (WML). METHODS: From -January 2016 to June 2017, a cross-sectional study was conducted on the clinical data of 358 WML patients over 65 years old in the Department of Neurology of the Daping Hospital. Mini-mental state examination scales were used to evaluate the cognitive function of the patients, and the cognitive impairment was diagnosed and grouped according to the scoring and diagnostic criteria. All WML patients were divided into the cognitive impairment group and normal cognition group. Clinical data of age, sex, education level, body mass index, abdominal circumference, smoking and alcohol consumption, blood pressure, fasting blood glucose, triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) were collected. Multivariate logistic regression analyses were performed to examine the relationship between MetS and cognitive impairment in WML patients. RESULTS: Compared with the normal cognition group, the proportion of MetS in the cognitive impairment group was significantly higher (χ2 = 11.211, p < 0.01), the proportion of MetS components such as elevated blood pressure, elevated blood glucose, elevated TG, decreased HDL-C and abdominal obesity in the cognitive impairment group was also higher (p < 0.01 or p < 0.05). After adjustment for age, sex, low education level, current smoking, daily drinking, severity of WML, MetS, and its components, multivariate logistic regression analysis showed that MetS was an independent risk factor for cognitive impairment in WML patients (OR 3.32, 95% CI 1.31-5.19). In addition, The greater the number of MetS components, the higher the risk of cognitive impairment in WML patients (ptrend < 0.01). CONCLUSION: MetS is an independent risk factor for cognitive impairment in patients with WML.


Subject(s)
Cognitive Dysfunction/etiology , Leukoaraiosis/complications , Metabolic Syndrome/complications , White Matter/pathology , Aged , Cognitive Dysfunction/pathology , Cross-Sectional Studies , Female , Humans , Leukoaraiosis/pathology , Male , Risk Factors
13.
J Clin Neurol ; 15(1): 46-53, 2019 Jan.
Article in English | MEDLINE | ID: mdl-30618216

ABSTRACT

BACKGROUND AND PURPOSE: This study investigated the contribution of white-matter hyperintensities (WMH) and lacunar infarcts (LI) to the risk of Alzheimer's disease (AD) in an elderly cohort in China. METHODS: Older adults who were initially cognitively normal were examined with MRI at baseline, and followed for 5 years. WMH were classified as mild, moderate, or severe, and LI were classified into a few LI (1 to 3) or many LI (≥4). Cognitive function was assessed using the Mini Mental State Examination and the Activities of Daily Living scale. RESULTS: Among the 2,626 subjects, 357 developed AD by the end of the 5-year follow-up period. After adjusting for age and other potential confounders, having only WMH, having only LI, and having both WMH and LI were associated with an increased risk of developing AD compared with having neither WMH nor LI. Moderate and severe WMH were associated with an increased risk of developing AD compared with no WMH. Furthermore, patients with many LI had an increased risk of developing AD compared with no LI. CONCLUSIONS: Having moderate or severe WMH and many LI were associated with an increased risk of developing AD, with this being particularly striking when both WMH and LI were present.

14.
Child Abuse Negl ; 88: 307-316, 2019 02.
Article in English | MEDLINE | ID: mdl-30553068

ABSTRACT

The current study examined the mediating effect of maternal negative expressiveness as well as the moderating effects of infant inhibitory control (IC) in the association between maternal childhood emotional abuse (CEA) and infant behavior problems. Drawing from 207 families from mainland China, 2-wave data were reported in this study when the infants were 6 months (T1) and 14 (T2) months. Mothers (Mean age = 32.85 years, SD = 4.04) reported their CEA on the Childhood Trauma Questionnaire-Short Form (CTQ-SF) at T1, and their negative expressiveness on the Self-Expressiveness in the Family Questionnaire (SEFQ) at T2. The Infant-Toddler Social and Emotional Assessment (ITSEA) and a reverse categorization task were used to measure infant behavior problems and IC at T2, respectively. The results showed that T1 maternal CEA, rather than physical and sexual abuse, uniquely predicted T2 negative expressiveness. Maternal negative expressiveness significantly mediated the positive relations of maternal CEA and infant externalizing, internalizing and dysregulation problems. In addition, the moderated mediation model showed that the association between maternal negative expressiveness and infant dysregulation problems was moderated by infant IC. Specifically, the mediating pathway from maternal CEA to dysregulation problems through maternal negative expressiveness was significant, only for infants with poor IC. The results were robust even after controlling for family socio-economic status (SES), maternal childhood physical and sexual abuse. The importance of mediating and moderating processes in understanding the effect of maternal emotional abuse during childhood on infant behavior problems is discussed.


Subject(s)
Child Abuse/psychology , Emotions , Mother-Child Relations/psychology , Mothers/psychology , Problem Behavior/psychology , Adult , Asian People/ethnology , Child , Child Abuse/ethnology , Child, Preschool , China/ethnology , Female , Humans , Infant , Infant Behavior/ethnology , Infant Behavior/psychology , Male , Risk Factors , Surveys and Questionnaires
15.
Parkinsonism Relat Disord ; 55: 68-74, 2018 10.
Article in English | MEDLINE | ID: mdl-29908727

ABSTRACT

INTRODUCTION: Metabolic syndrome (MetS) increases the risk of cognitive impairment in normal aging but this has not been studied in Parkinson's Disease (PD). The purpose of this study was to investigate the impact of MetS on cognitive impairment in PD. METHODS: This study investigated subjects older than 60 years who were diagnosed with PD. They were enrolled into this study between January 2010 and December 2011, and followed for 5 years. The assessment of cognitive function in subjects with PD was based on the cognitive and neuropsychiatric tests, and MetS was diagnosed according to the National Cholesterol Education Program's Adult Treatment Panel III. The subjects were divided into three groups according to the cognitive function at the end of follow-up: PD with normal cognitive function (PD-NC), mild cognitive impairment in PD (PD-MCI) and PD dementia (PDD). RESULTS: Of the 787 subjects with PD included in our study, 255 (32.4%) were diagnosed with PD-MCI, and 105 (13.3%) were diagnosed with PDD. MetS was significantly associated with PD-MCI (odds radio [OR]: 1.45, 95% confidence interval [CI]: 1.17-1.72) and PDD (OR: 2.12, 95% CI: 1.57-2.83). The associations between MetS and the main cognition domains of PDD were statistically significant. The treatment of MetS was helpful in reducing the risk of PDD. CONCLUSIONS: We found that MetS increase the risk of cognitive impairment in patients with PD, and is significantly associated with the severity of cognitive impairment. The results suggest that the intervention against MetS is helpful in managing cognitive impairment in PD.


Subject(s)
Cognitive Dysfunction/etiology , Metabolic Syndrome/complications , Metabolic Syndrome/etiology , Parkinson Disease/complications , Aged , Aged, 80 and over , Blood Glucose , Cholesterol/blood , Cognitive Dysfunction/epidemiology , Female , Humans , Longitudinal Studies , Male , Metabolic Syndrome/drug therapy , Middle Aged , Neuropsychological Tests , Parkinson Disease/epidemiology , Regression Analysis , Severity of Illness Index
16.
Mol Neurobiol ; 55(10): 8179-8187, 2018 Oct.
Article in English | MEDLINE | ID: mdl-29516283

ABSTRACT

Polymorphisms of the cholesterol-24S-hydroxylase (CYP46A1) and apolipoprotein E (APOE) genes are risk factors for Alzheimer's disease (AD). Plasma level of 24S-hydroxcholesterol (24-OHC), the metabolite of cholesterol, is thought to correlate with AD. The present study investigated the correlation between these genetic factors and blood 24-OHC and amyloid-beta (Aß) levels in AD patients. Association analysis, logistic regression, and linear regression were used to analyze the correlation of CYP46A1 and APOE genotypes with blood 24-OHC and Aß levels and AD risk. We found that the APOEε4 alleles were significantly higher in patients with AD and there was a potential synergistic interaction between the CYP46A1 C allele and APOEε4 allele in AD. Blood 24-OHC level and Aß level were significantly higher in AD patients than controls, indicating 24-OHC could be a marker in AD diagnosis. However, AD patients with the CYP46A1 TT, but not CC, genotype had higher 24-OHC levels, which indicated that there may be other mechanisms in the relationship between CYP46A1 polymorphisms and AD.


Subject(s)
Alleles , Alzheimer Disease/genetics , Apolipoproteins E/genetics , Cholesterol 24-Hydroxylase/genetics , Genetic Predisposition to Disease , Polymorphism, Single Nucleotide/genetics , Aged , Alzheimer Disease/blood , Amyloid beta-Peptides/blood , Case-Control Studies , Demography , Female , Genetic Association Studies , Humans , Hydroxycholesterols/blood , Male , Risk Factors , Severity of Illness Index
17.
Neurol Sci ; 38(11): 1933-1939, 2017 Nov.
Article in English | MEDLINE | ID: mdl-28785821

ABSTRACT

The risk factors for post-procedural events after carotid artery stenting (CAS) have not been well established. The aim of this study was to investigate the association between metabolic syndrome (MetS) and the risk of post-CAS complications. A total of 358 consecutive patients who underwent CAS were enrolled in this prospective study. Patients' demographic data, clinical characteristics, and complications after CAS within 30 days were recorded. Logistic regression analysis was performed to identify possible risk factors for post-procedural complications after CAS. The incidence of complications after CAS within 30 days was 7.0%. Logistic regression analysis identified the following as independent risk factors for 30-day transient ischemic attacks, stroke, myocardial infarction, and death after CAS: metabolic syndrome (OR = 2.31, 95% CI 1.91-3.01, P = 0.004), diabetes (OR = 2.24, 95% CI 1.74-2.76, P = 0.026), symptomatic patient (OR = 1.73, 95% CI 1.23-3.05, P = 0.011), and age (OR = 1.87, 95% CI 1.35-2.57, P = 0.042). Among the components of MetS, central obesity (OR = 2.21, 95% CI 1.24-2.63, P = 0.006), low high-density lipoprotein cholesterol (HDL-C) (OR = 1.66, 95% CI 1.34-2.27, P = 0.022), and high fasting plasma glucose (OR = 2.32, 95% CI 1.85-2.74, P = 0.003) were associated with increased risk of 30-day complications after CAS. This present study suggests that patients with metabolic syndrome have significantly increased risk of complications after CAS within 30 days. Moreover, MetS patients with central obesity, high fasting plasma glucose, or low HDL-C have significantly increased risk of complications after CAS within 30 days.


Subject(s)
Carotid Arteries/surgery , Carotid Stenosis/surgery , Metabolic Syndrome/complications , Metabolic Syndrome/epidemiology , Postoperative Complications/epidemiology , Stents , Aged , Aged, 80 and over , Carotid Stenosis/complications , Female , Follow-Up Studies , Humans , Incidence , Logistic Models , Male , Middle Aged , Prospective Studies , Risk Factors
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